Made in Japan Japan – the island nation is famous for many things.
The first developed country in Asia despite adverse geographical conditions,
the oldest empire existing on earth, the land of rising sun, Japanese tea
ceremony Sado, Sushi the national dish, the great Samurai warriors, the
gigantic Sumo wrestlers and above all
“Made in Japan” robots. Its technology had made it an iconic nation. I was amazed to see many marvels of science and
technology during my recent visit to Tokyo Science Center. What impressed me most
was apart from being a research and training center for healthcare
professionals it offers many novel modes of training like using realistic organ
models for endoscopic surgery and cardiovascular disease treatment in an effort
to introduce its cutting edge medical devices and technological advancement to
the whole world enabling the healthcare professionals to enhance their
knowledge and skills in treating patients across the globe for unmet medical
needs making it a…
Dissolution is the process by which a solid enters into solution.
In 1897 Noyes and Whitney came up with: “The rate of solution of
solid substances in their own solution.”
dc / dt = K (Cs-Ct)
According to their research, rate of dissolution of solid substances is determined by rate of diffusion of a very thin layer of saturated solution that forms instantaneously around the solid particle. They developed the mathematical relationship that correlates the dissolution rate to the solubility gradient of the solid.
Diffusion layer model / film theory
In 1904, Nerst and Brunner applied Fick’s law of diffusion to the
Noyes-Whitney equation. (Diffusion layer model / film theory)
dc / dt = K D.S / v.h (Cs-Ct)
Cube root law of dissolution
In 1931, Hixson and Crowell came up with Cube root law of
W01/3-W1/3 = Kt
Scheme of dissolution
Later Wagner followed by Carstensen gave the scheme of dissolution.
Initial mechanical lag
Wetting of the …